Prellis Biologics uses proprietary technology to 3D print lymph node organoids, which we are using to generate in vitro antibody libraries and in vitro human lymph node cocultures for generating antigen-specific B-cells. We are seeking a Research Associate – Senior Research Associate, Antibody Screening and Characterization to join our Antibody Screening team. This role will report to a Senior Scientist in the Antibody Screening team working on internal QC and high-throughput antibody screening. The ideal candidate will have a strong background in molecular biology, with significant experience in supporting end-to-end antibody discovery campaigns.

Key Responsibilities:

• Support high-throughput antibody screening and characterization using BLI and SPR technologies to assess binding kinetics, specificity, and affinity across multiple antibody discovery projects.
• Develop, optimize, troubleshoot, and execute a range of ELISA-based immunoassays to support high-throughput antibody screening, validation, and characterization.
• Work with custom laboratory automation systems and liquid handling platforms to enable high-throughput workflows.
• Collaborate closely with cross-functional teams, providing technical support through proactive communication.
• Maintain accurate and detailed experimental records and present results clearly in team and project meetings.
• Independently troubleshoot assays and contribute to protocol optimization for enhanced robustness, efficiency, and throughput.

Qualifications:

• B.S in Molecular Biology, Immunology, Biotechnology, or related life science field with 4+ years of experience, or M.S. with 2+ years of relevant experience in an industry or equivalent research setting.
• Strong hands-on experience with BLI-based antibody screening (e.g. Octet); Familiarity with Carterra® LSA/LSAXT or Biacore™ SPR is a strong plus.
• Hands-on experience in small-scale protein purification using chromatography resins is a strong plus.
• Hands-on experience with lab automation systems or liquid handlers, such as Biomek and Lynx.
• Ideal candidates will have prior experience in antibody discovery workflows with the goal of identifying novel therapeutic candidates.
• Excellent organizational and time management skills, with the ability to contribute to multiple projects in a fast-paced, collaborative environment.
• Excellent written and verbal communication skills, with the ability to document, interpret, and present experimental results clearly.
• Experience with performing high-throughput protein QC/analytical assays following protein purification (SDS-PAGE, affinity chromatography and size-exclusion chromatography) is a plus.

About Prellis Biologics At Prellis we integrate human biology with machine learning. We aim to revolutionized drug discovery by harnessing the power of human immune system with tightly, integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human body candidate rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before. Prellis Biologics is a pre-IPO biotech located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and oncology disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, & Avidity Partners.

What You Can Expect Of Us As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Application deadline Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.