Prellis Biologics uses proprietary technology to 3D print lymph node organoids, which we are using to generate in vitro antibody libraries andinvitrohumanlymphnodecoculturesfor generating antigen-specific B-cells.We are seeking a Head of Antibody Optimization to join our Research group.As part of the Prellis Therapeutic Antibody Engineering team, you will report to CSO with accountability for engineering of development candidates, leading with a fully collaborative spirit, drive, enterprise mindset, and a team-centric and inspiring attitude. The ideal candidate will have a strong background in molecular biology, protein engineering, and a deep understanding of antibody and protein structure-function relationships.

Key Responsibilities:

• Oversee the design, strategy, and technical development of novel antibody therapeutics for advancement to IND-filing, focusing on enhancing specificity, affinity, stability, and manufacturability
• Lead the conceptualization, design, and cloning of innovative bispecific or similar multi-specific antibody formats, including dual targeting and crosslinking capabilities
• Lead the construction of expression vectors and the production of reagent proteins and recombinant antibodies in various systems (e.g., mammalian, bacterial, insect)
• Collaborate tightly with our Data Science team, and utilize computational tools and modeling techniques, to predict and optimize antibody-antigen interactions, antibody pharmaceutical properties, and structural stability
• Analyze experimental data and present findings to cross-functional teams and senior management.

Qualifications:

• Ph.D. in Molecular Biology, Biochemistry, Immunology, or a related field witha strong academic record.
• OutstandingM.S.candidates with relevant experience will be considered
• Minimum of 5 years of experience in antibody engineering or a related area, with a strong understanding of antibody and early drug discovery and development, along with a proven track record of successful project leadership and innovation
• In-depth understanding of antibody structure-function relationships, protein engineering strategies, and therapeutic antibody discovery and development
• Expertise in molecular cloning, protein expression, and purification
• Rigorous scientist with strong problem-solving skills, excellent written and verbal communication skills, and the ability to work collaboratively in a fast-paced, multidisciplinary environment
• You have demonstrated the ability to work in a dynamic environment and adapt to changing priorities and deadlines to deliver projects within scope, budget, and timeline
• Title commensurate with experience

About Prellis Biologics

At Prellis we integrate human biology with machine learning. We aim to revolutionized drug discovery by harnessing the power of human immune system with tightly, integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human body candidate rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before.Prellis Biologics is a pre-IPO biotech located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and oncology disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, & Avidity Partners.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Prellis offers compelling benefits based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A competitive employee benefits package, including group medical, dental and vision coverage, life and disability insurance, flexible spending accounts an a 401(k) plan
• Stock-based long term incentives
• Holiday package including a 1+ week winter shutdown
• Flexible work models, including remote and hybrid working arrangements, where possible

Application deadline

Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.